Prague to Santiago normally runs €900–€1,400 round trip. At €608, that's roughly 40–55% off for one of the longer routes you can fly to South America from Prague for under €650 is rare.

September and early October is the start of spring in Chile — warming up after winter, wine country at its best before the summer tourist surge, and Patagonia still accessible before the peak season crowds arrive in November and December. If you've been thinking about South America, this is the price that makes it actually happen.

Santiago is one of the best bases in South America. Day trips to the Maipo Valley wine region, Valparaíso's street art and hillside trams, and the Andes for skiing or hiking are all within two hours. Most fill up fast in spring.

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